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Combined effect of chrysin and apigenin on inhibiting the development and progression of colorectal cancer by suppressing the activity of P38-MAPK/AKT pathway

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Gempel K, Topaloglu H, Talim B, Schneiderat P, Schoser BG, Hans VH, Plmafy B, Kale G, Tokatli A, Quinzii C, Hirano M, Naini A, DiMauro S, Prokisch H, Lochmller H, Horvath R

Active gene promoters are enriched with activation marks such as H3K27ac, which loosen chromatin structure [41], while repressive regions are covered by marks such as H3K27me3 to maintain a heterochromatic state [42, 43]