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Gut microbial-derived butyrate inhibits sirtuin 3 and mitochondrial complex I in tumor cells to prevent the conversion of TCA cycle intermediates to adenosine triphosphate (ATP)

Human glutathione S-transferases- and NAD(P)H:quinone oxidoreductase 1-catalyzed inactivation of reactive quinoneimines of amodiaquine and N-desethylamodiaquine: possible implications for susceptibility to amodiaquine-induced liver toxicity

If necrosis dominates, overt renal failure ensues

They can be classified into two main types: internal and external

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