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Furthermore, GSTs are additionally identified as regulators of cellular signaling pathways, thereby influencing cell proliferation or apoptosis ( in vitro with chemically reactive metabolites derived from several drugs displaying idiosyncratic toxicity, including troglitazone, acetaminophen, clozapine, and diclofenac ( HepG2 cells have been used for decades as a test system for studies involving hepatotoxic compounds

Effect Duration Begins working within a few hours to a couple of days in most patients, especially when correcting deficiencies

Pregnancy and breastfeeding require avoiding both compounds entirely

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