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Intestinal inflammation can trigger systemic and central inflammatory responses

In FOXO4-DRI (D-retro-inverso-isoform peptide), L-amino acids are substituted by D-amino acids that mimic the FOXO4 p53 binding domain
136 , 1731S1740S (2006)

Body weight may influence dosing for some compounds (especially weight-based dosing for FDA-approved indications)

5E, right panel) a N-1 binary comparison test was performed