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Therefore, depletion of NADPH stores in G6PD-d has the potential to both limit the production of ROS by NOX family enzymes, while simultaneously expediting the accumulation of ROS from non-NADPH-dependent sources, such as the mitochondrial electron transport chain, peroxisomal -oxidation, oxidative protein folding, and other cytoplasmic enzymes (xanthine oxidase, cyclooxygenase, lipoxygenase) 95,96

Kovik A

PMC 10506345

UU.) equipped with a flame ionization detector and a capillary column GC (60 m x 0.25 m

Andreeff M , Escudier A, Goodacre A, Stilgenbauer S, Engel H, Walker S, Gahn B, Keyhani A, Shi G, Drach J, Zhao S, Liu Y, Rondon G, Jendiroba D, Cabanillas F, Siciliano M, Champlin R, Younes