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One multicenter RCT reported no differences at four months of follow-up in total symptom scores between PPS (200 mg twice daily) and placebo patients with statistically similar rates of clinically significant improvement in both groups (56% versus 49%, respectively)

The subsequent series of adverse events include loss of membrane integrity, mitochondrial dysfunction, impaired sperm motility as well as DNA damage and apoptosis resulting in damage of cellular components and pathogenesis of reproductive diseases and infertility ( Thus, information obtained from the assessment of OS status could be of great importance in enhancing clinical decision making

10.1016/j.ejca.2009.12.008 35 CebullaN.SchirmerD.RunauE.FlammL.GommersbachS.StengelH.et al (2023)

This procedure involves intravenous anesthesia, neuromuscular block, and mechanical ventilation