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Heberer T (2002) Occurrence, fate, and removal of pharmaceutical residues in the aquatic environment: a review of recent research data

Notably, the TFs with strong cellular and transcriptional phenotypes have been implicated previously in neurological disorders: ARX in X-linked lissencephaly 57 , epilepsy 58,59 and intellectual disability 60,61 , and autism spectrum disorder (ASD) 58

These data suggest that the hypoxic response might affect the Ras/ERK signaling pathways downstream to neurofibromin loss and its genetic inactivation installs a hypoxic-like response that may provide cells with an equipped and prompt response to any possible drop in oxygen availability

Hyperhomocysteinemia and elevated MMA can also arise from Imerslund-Grsbeck syndromea rare autosomal recessive disorder caused by mutations in either the CUBN or AMN gene responsible for the synthesis of IF receptors (cubam) in the ileum (distal region of the small intestine) (35)

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