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Research confirms that Pycnogenol enhances endothelial NO production by increasing endothelial nitric oxide synthase (eNOS) activity and protects the generated NO from degradation by scavenging superoxide anion radicals, thereby improving its bioavailability (250)
Additionally, the treatment led to decreased levels of several key SASP factors, including IL-1, IL-6, and TGF-, in testicular tissue
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