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Oxidative stress is also a contributor to muscle wasting, as ROS are well-known stimulators of apoptotic pathways, showing that oxidative stress is a factor in muscle wasting ( Fig
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It simply means that if your body demands more due to higher activity levels, 3000 can offer that additional edge

J Inherit Metab Dis 33:469477

After correction for multiple testing, coumarin remained the most robustly altered metabolite, indicating a modest but statistically supported response to dietary intervention