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Common gastrointestinal side effects include: Nausea the most frequently reported side effect, particularly during dose escalation Vomiting often linked to nausea and typically dose-dependent Diarrhoea and constipation both have been reported, reflecting altered gut motility Decreased appetite a desired therapeutic effect, but one that requires monitoring to ensure adequate nutrition Severe or prolonged vomiting and diarrhoea can lead to dehydration and, in some cases, acute kidney injury (AKI)

c , Spot assay of growth on solid YPD medium starting at 10 6 cells ml -1 with 10-fold serial dilutions

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To view a copy of this license, visit About this article Cite this article Marxen, S., Stark, T., Rtschle, A