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Description
It drives the formation of new synapses

As a therapeutic option, combined treatment with asparaginase and an anti-PD-1 antibody could be useful because glutamine-addicted cells are sensitive to asparaginase 149
By providing exogenous pyridoxine that is readily converted to PLP, the injection corrects the coenzyme deficiency and reactivates these metabolic pathways

PMID: 150 ZhangYXZhaoYYShenJSunXLiuYLiuHet al

Under normal conditions, PINK1 accumulates on damaged mitochondria, recruits Parkin, and triggers their elimination by autophagy