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Gray matter is a tissue found in the brain and spinal cord

Epigenetic changes, including aberrant DNA methylation and histone modification, further contribute to altered gene expression and sustained oncogenic signaling [226,227]

Bergsbaken T, Fink SL, Cookson BT (2009) Pyroptosis: host cell death and inflammation

Basit F, van Oppen LMPE, Schckel L, Bossenbroek HM, van Emst-de Vries SE, Hermeling JCW, et al

Altogether, loss of function experiments demonstrated the importance of TET enzymes in cell differentiation during development and similarly, several studies also analyzed the impact of the removal of DNMTs through development