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MOTS-c has a plasma half-life of approximately 2 hours, but its metabolic effects persist for 68 hours due to downstream signalling cascades

Frequently Asked Questions Did AOD-9604 show any weight loss benefit in clinical trials

Recommended Timing Protocols Morning Fasted Protocol (Most Common): Timing: Upon waking, before any food or caloric beverages Fasting Window: At least 8-10 hours fasted from overnight sleep Post-Injection: Wait 30-60 minutes before eating breakfast Activity: Light fasted cardio or morning routine before first meal may enhance fat mobilization Advantages: Convenient, consistent daily routine, maximizes overnight fasted state Pre-Exercise Protocol: Timing: 30-45 minutes before fasted cardio or training session Fasting Window: At least 4-6 hours since last meal Rationale: Exercise during fasted state with elevated free fatty acids may enhance fat oxidation Considerations: Not suitable for high-intensity training

Zhou, F., Zhang, H., Cong, Z., Zhao, L

CDC data show that 38% of U.S