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Topic antiperspirants containing aluminum chloride, are known to be the first line of therapy for axillary hyperhidrosis, however, they are ineffective in the treatment of palmar or plantar hyperhidrosis as the skin is much thicker (7, 8)

The metallic debris (Ti particles and nanoparticles) released at the peri-implant site can be phagocytized by the circulating immune cells (neutrophils, monocytes) and macrophages, which become stimulated to release pro-inflammatory cytokines (IL-1, IL-6, IL-8) and free radicals