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Hypoxia has a differential impact: CD8 + and Th1 cells are highly sensitive to hypoxic stress, while Tregs and M2 TAMs adapt by enhancing mitochondrial respiration and shifting to FAO

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26 Consistent with this, -synuclein overexpression in worm dopaminergic neurons using the dat-1 promoter (P dat-1 ) induces neurodegeneration in the six anterior dopaminergic neurons (Supplementary Figure S1a)

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