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However, once activated VEGFR-2 dissociates from caveolin-1, and VEGFR-2 is subsequently phosphorylated, endocytosed, and degraded (35, 52, 53)

Moreover, they stimulate the production of various pro-inflammatory mediators, including cytokines such as TNF and interleukins (IL-1 , IL-6, IL-12, IL-17, IL-18, IL-23), chemokines like CCL12 and CXCL10, as well as other pro-inflammatory agents, including ROS and RNS, inducible iNOS, and cyclooxygenase-2 (COX-2) 143

The RT-qPCR analysis was performed on 100 ng of total RNA using iTaq Universal SYBR Green One-Step Kit (Bio-Rad, CA)

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Our skin is constantly subjected to physical and environmental factors, which can worsen its condition over time