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[ 88 , 94 , 472 , 474 , 475 ] Keap1, the most validated target for NRF2 activation, is a redox sensor containing several cysteine residues, whose oxidation or modification compromises either dimeric structure formation or combination to ubiquitin ligase, resulting in NRF2 protein release and nuclear import

Redox-coupled crystal structural changes in bovine heart cytochrome c oxidase

OS is associated with a higher number of immature spermatozoa through an indirect effect on male hormone production, which is associated with spermatogenesis (48, 49)

doi: 10.1038/s41587-019-0201-4, 17