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In contrast, the NP in mice have a highly cellularity, while the human NP have a greater proportion of ECM

This pressurizes the vial and makes it much easier to draw the liquid out

The area of the caudal corpus callosum was significantly larger in mice fed pelleted cuprizone than those fed control pellets (p 0.05

This suggested that SF was exerting a pharmacodynamic action that reflected induction of GSTs by SF, thereby shunting the reactive epoxide intermediate away from nucleophiles in DNA, where it would have mutagenic and carcinogenic effects, and toward GSH, which allowed it to be further metabolized and excreted in the urine

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