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34 In the mitochondria, it is involved in numerous bioenergetic reactions, including a critical step bridging glycolysis and the citric acid cycle

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The bioavailability of supplemental acetyl-L-carnitine has not been as well studied, though some evidence suggests slightly higher circulating concentrations compared to equivalent L-carnitine doses, with peak plasma levels typically achieved 24 hours after oral administration [5][12]

Fatty acids brought into the mitochondria via CPT-1 are broken down into acetyl CoA via -oxidation