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Siegel, 1961): Absorption tests with food, using a flushing vitamin B12 injection to estimate absorption, indicate a reduction of the passive absorption by about 40% when supplements are taken with food rather than when fasting

or 8 p.m

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It's generally obtained from foods such as meat, fish, milk and eggs but deficiency is very common and is often caused by a diet lacking meat and dairy

For more detailed scientific research on B12, the National Institutes of Health offers excellent resources