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This subsequent step involves conjugation reactions, such as glucuronidation, sulfation, or acetylation, which yield highly polar, inactive metabolites that are readily excreted in the urine or bile

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Studies indicate that inhibiting TXNIP expression or the dissociation of thioredoxin (Trx) from TXNIP can reduce NLRP3 activation and inhibit pyroptosis onset (Jia et al., 2020

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