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Notably, Pyrimethamine has been described as an inhibitor of the transcription factor STAT3 in human cells [58] and as a mediator that destabilizes aminoacyl-tRNA synthetase-interacting multifunctional protein 2 (AIMP2) [59]

10.1249/01.mss.0000145465.71269.10 Med

No clinical trial has tested this combination, but the pharmacological logic supports the approach for researchers operating at the cutting edge

Common reconstitutions: 5mg BPC-157 + 2.5ml bacteriostatic water = 2mg/ml (200mcg per 0.1ml) 5mg BPC-157 + 5ml bacteriostatic water = 1mg/ml (100mcg per 0.1ml) 10mg BPC-157 + 5ml bacteriostatic water = 2mg/ml (200mcg per 0.1ml) Easy math: 5mg + 2.5ml water means each 0.1ml (10 units on insulin syringe) = 200mcg

Avoid mixing copper peptides with strong, lowpH actives like highstrength vitamin C (ascorbic acid), aggressive AHAs/BHAs (glycolic, lactic, salicylic acid), and potent retinoids in the same step, as they can destabilize peptides or increase irritation