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Br J Pharmacol 171:21232146 Olson KR, Straub KD (2016) The role of hydrogen sulfide in evolution and the evolution of hydrogen sulfide in metabolism and signaling

Abetalipoproteinemia is characterized by fat malabsorption, steatorrhea, acanthocytosis (thorny looking cells), and hypocholesterolemia in infancy

Untargeted lipidomics and data analysis Approximately 30 mg liver tissue from mice treated with AAV8-AGXT or AAV8-GFP was used for untargeted lipidomics
A well-designed carrier system can shield B12 from degradation, facilitate its transport through the GI tract, control its release at the appropriate site in small intestine (the ileum), and promote efficient absorption

All participants (n = 96) completed a single 24-h collection period, beginning at 12 PM on day one and ending at 12 PM on day two