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In contrast, radiation promotes cuproptosis by increasing mitochondrial copper through upregulation of the copper importer solute carrier family 31 member 1 (SLC31A1, also known as CTR1) while simultaneously depleting mtGSH, thereby shifting copper homeostasis toward toxicity 170

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Over 68 weeks in the REDEFINE trials, cagrilintide 2.4 mg alone achieved approximately 10.8% body weight reduction