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The past and current findings on the mutational profile of cutaneous melanoma are opening new doors to understand how this tumor initiates, progresses and metastasizes and are leading to a new orientation for antitumor therapy, referred as targeted therapy, which offers the opportunity for various treatment options that can be used in combination with other treatment modalities, i.e., surgical resection, chemotherapy, radiotherapy, and immunotherapy

Ananthakrishnan AN, Bernstein CN, Iliopoulos D, Macpherson A, Neurath MF, Ali RAR, et al