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10.1016/j.ijantimicag.2021.106372 Int J Antimicrob Agents

As expected, PFK15 treated T cells had downregulated levels of the key glycolysis proteins Glut-1, HK2, PFKFB3, and LDHA and reduced supernatant lactate levels as compared to control BDC2.5 T cell clones, confirming an inability to engage in glycolysis upon encounter with cell antigen ( Figures 6D, E )

Of particular interest: 47 DNA repair genes were stimulated and 5 were suppressed

Mitochondrial quality control mediated by PINK1 and parkin: links to parkinsonism

In addition, Mn overexposure may affect tyrosine hydroxylase (TH), an enzyme required for dopamine synthesis in dopaminergic terminals