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Activation of these receptors triggers two complementary processes: it accelerates lipolysis (the breakdown of stored triglycerides into free fatty acids for energy) while simultaneously inhibiting lipogenesis (the conversion of glucose and other substrates into new fat stores)

Vegetarians, older adults, and those with absorption issues are at higher risk

A 2024 review documented studies across gastric, intestinal, musculoskeletal, vascular, neural, and dermal tissue (PMID 38980576)

Senescence represents a permanent state of cell cycle growth arrest, induced by various stressors including telomeric attrition and oncogenic signaling (100)