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doi: 10.1038/nature04140

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The mechanism centers on several overlapping actions: Angiogenesis activation: BPC-157 upregulates VEGF (vascular endothelial growth factor), promoting the formation of new blood vessels that supply oxygen and nutrients to damaged tissue

These effects are diminished or lost in 3-KO mice, indicating that 3-AR signaling is essential for many, but not all, of AOD9604s actions

Cancer Treat Res
