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However, the subcellular localization or lack of metal ions may limit the antioxidant effect of enzymes

In pancreatic cancer, cancer-associated fibroblasts (CAFs) drive resistance to platinum through the nuclear translocation of PKM2, the upregulation of the expression of glycolysis-related genes, and the secretion of IL-8, all of which enhance DNA damage repair [59]
and Singh, I., 1994

We elaborate on metabolic changes for macrophages, neutrophils, vascular endothelial cells, vascular smooth muscle cells and lymphocytes in the context of atherosclerosis and its co-morbidities hypertension, dyslipidemia, and diabetes

risk of abnormal male genital development in male fetuses