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Interleukin-1 Interleukin-1 (IL-1) is markedly elevated in intestinal mucosa under inflammatory conditions, such as CD patients.44 In clinical studies, an IL-1 receptor antagonist is currently being developed for therapeutic usage, which indicates IL-1 plays a central role in the intestinal inflammatory process.45 Furthermore, recent studies show that IL-1 causes increased intestinal TJ permeability

It is administered as a once-weekly injection, with doses adjusted gradually to reduce side effects

Vitamin B refers to eight water-soluble vitamins , each with specific and essential roles in maintaining bodily functions

the dosing schedule differs

Firstly, not all patients respond well to oral tablets and, secondly, the tablets prescribed are not guaranteed to be pharmaceutical standard and are instead regulated by the Food Standards Agency