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Educational communication should remain focused on accurate biologic mechanisms, signaling pathways, and responsible clinical positioning

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doi: 10.1038/s41598-021-86425-6 193 ProalAMarshallT
The honest boundary is that even the coherent pairing is a mechanistic hypothesis with no human validation, so the most defensible research posture is to study the single compound at its documented dose first, and treat any combination as a further, clearly-labelled research question rather than a default

10.1111/j.0022-202X.2005.23823.x 53
