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NAC for the Treatment of Depression Chronic pain and depression often coexist, and activation of specific brain regions that are associated with the so- called pain matrix, including the insula, cingulate cortex, and amygdala, play a key role in the regulation of mood and in the mechanisms of resilience to stress

Nrf2 regulates the arginase 1+ microglia phenotype through the initiation of TREM2 transcription, ameliorating depression-like behavior in mice

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