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MODIFICATION OF KEAP1 PROTEIN THROUGH ONCOMETABOLITES While unique metabolic activities in cancers, such as aerobic glycolysis, have long been recognized (Ward et al., 2010)

5 Different hypotheses for NF-B activation and their future endorsement: Role of PHDs 5.1 PHDs as a dual regulator of HIF-1 and NF-B While HIF-1 is an extensively studied transcriptional regulator under hypoxia, other transcriptional regulators exist (Nakayama and Kataoka, 2019)

10.1161/CIRCRESAHA.122.319983 187 HonarpishehP.ReynoldsC

Morphological switch can be induced by temperature (thermal dimorphism), as in the case of the dimorphism induced once they get inside the mammalian host and reach 37 C