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pmid:31549445 6

Lieu C, Heymach J, Overman M, Tran H, Kopetz S

Cell types of the human retina and its organoids at single-cell resolution
The defect begins below the receptor When insulin binds to its receptor, it initiates a signalling sequence through the phosphoinositide 3-kinase/Akt/mTOR pathway (PI3K/Akt/mTOR), which governs glucose transporter type 4 (GLUT4) translocation the step that allows glucose to actually enter the cell
