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Most compounds that target tumor metabolism (methotrexate, 5-fluorouracil) fail to distinguish between tumor tissue and rapidly differentiating epithelial tissue (skin, bone marrow), 4,322 whereas therapies targeting the specific amino acid dependence of tumor cells are cell-selective, such as leukemic blasts that are selectively dependent on Asn, the use of bacterial-derived ASNase in pediatric ALL has significantly improved the cure rate

So, serious side effects are extremely rare

Using too little water Adding 0.5mL to a 10mg vial yields 20,000mcg/mL, where a 250mcg dose is barely over 1 unit difficult to measure accurately

In tumor-bearing rats, LC protects hepatic lipid metabolism, indicating that supplementation might be beneficial in cachexia (Silvrio et al., 2012)