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Description
S1P is produced when sphingosine is phosphorylated by sphingosine kinase (SPHK)
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Solute carrier family member 7, 11 (SLC7A11), the Xc subunit of the cystine/glutamate antiporter system which inhibits ferroptosis, is upregulated in PAH patients and hypoxia-induced PAH rat models [52]
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The lack of a significant correlation between purine metabolites and 5-HIAA, suggests alterations in key 5-HT pathways that may both be modified by and contribute to oxidative stress via purine catabolism in FENNS
