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While the -2a or isoform of OGG1 was initially presumed to be the main mitochondrial isoform [135], a recent study demonstrated that the endogenous mitochondrial-targeting sequence of the predominant -1a isoform is sufficient to target both the nucleus and mitochondria [151]

However, cancer cells are inherently pro-oxidative [161] and are unable to cope with the additional stress, which eventually leads to apoptosis [164, 165]

Cerebellum 12 , 4347 (2013)

PMID: 35123548

Patients present with conditions that demand specific concentrations, unique ingredient combinations, or vehicles that commercial products simply dont offer