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The conflicting findings regarding M1 and M2 macrophage polarization suggest that the effects of NAC may be context-dependent, influenced by factors such as concentration, cell type, and specific microenvironmental conditions

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For example, lipid peroxidation is a process where ROS can interact with the lipid's electrons and thus alter its structure and characteristics, leading to important disturbances in the bi-layer lipid membranes of the cell, which can have strong effects on cell homeostasis and signalization, as well as survival