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In particular, rats subjected to I/R and pretreated with HPE displayed a significant decrease in hepatic damage markers such as ALT, AST, LDH and MDA

[259] designed a novel doxorubicin prodrug (pDox) that responds to ROS in the TME

At the titrated once-daily doses, roughly one vial covers a 34 week phase at these once-daily doses, so plan several vials for a full course

Gene ontology of genes in the NRF2 cistrome that were also upregulated by BDG exposure were enriched for the biological processes: response to oxidative stress, cell-cell adhesion, cytokine signaling, and glutathione metabolism ( Figure 3D and Supplementary Table 5B )

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