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Although it is known that abnormal lipid metabolism and adipose tissue accumulation possibly play important roles in linking obesity and T2D, the actual mechanisms are still unclear because not all obese people are insulin resistant or at high risk of diabetes [9]

Guieu R, Ruf J, Mottola G

Theres some evidence linking decreased levels of SAMe in the body with the development of liver diseases, and animal studies have suggested that SAMe may be of value for liver problems
doi: 10.1016/j.taap.2008.01.021

This increases the likelihood of the addiction aspect
