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This study further suggested that AMPD3 may induce cardiometabolic changes through AMPD3-BCKDH expression imbalance in cardiomyocytes of diabetic individuals, providing new insights into the mechanism of the development of this disease

[DOI] [Google Scholar] Brinkmann Y

However, the extent to which central pain modulation contributes to abdominal pain in FC remains unclear

This review summarises key contraindications, clinical situations requiring caution, relevant drug interactions, and commonly reported adverse effects associated with KD

A Cochrane review supports the use of high-dose vitamin B 12 (1 mg and 2 mg daily) in elevating serum vitamin B 12 level and achieving haematological and neurological responses, even in patients with PA or with ileal resection.58 The recommendation for oral replacement is 1 mg daily for a month, and then 125 to 250 g daily as maintenance dose for patients with dietary insufficiency and food-cobalamin malabsorption, while for PA the maintenance dose is 1 mg daily.29 Vitamin B 12 does not have side-effects even when prescribed in large doses.59 However, hypokalaemia, resulting from uptake of circulating potassium by newly growing and dividing haematopoietic cells, can be severe or sometimes life-threatening