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Given that B12 is a water soluble vitamin, Meshulam says that an excess is not harmful and is typically excreted through urine

And if your B12 levels are normal, getting B12 injections isnt going to do anything

However, there is no scientific evidence supporting B12 supplementation for direct fat loss in individuals with normal B12 levels

The study sought to clarify whether AOD-9604 produced its reported fat-reducing effects through the same receptor pathway as native growth hormone, and whether the 3-AR pathway was required for activity

This direct approach ensures that the vitamin is absorbed efficiently, especially in individuals who may have difficulty absorbing B12 through the digestive tract due to certain health conditions