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NAC has a stronger evidence base than direct glutathione supplementation and is actually used in NHS hospitals for paracetamol overdose due to its ability to replenish hepatic glutathione
Additionally, the accumulation of GSSG and depletion of GSH can be directly toxic to cells by activating the SAPK/MAPK apoptotic signaling pathway, which leads to programmed cell death [29,83,98,99]

Dutta, D
Alternative approaches aim to target downstream pathways of serine/glycine/one-carbon metabolism

Glutathione responsive polymers and their application in drug delivery systems Polym Chem
