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The outer surface of CTL1 is mostly neutral to positively charged, whereas distinct positive (Lys544, Lys454, Arg457, His584, and Lys491) and negative (Asp537, Glu591, and Asp595) patches are observed close to the entrance of the proposed binding pocket (Fig 4G)
doi: 10.1016/j.ejphar.2006.06.026
