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Qiao, R
Phosphorylation by aurora kinase A induces Mdm2-mediated destabilization and inhibition of p53
The active form of B6 is called pyridoxal 5-phosphate or P5P
139,140 In addition, recently, IDH1 and IDH2 gene mutations have been prevalent in several diverse malignancies, including glioma, AML, angioimmunoblastic lymphomas, chondrosarcoma, and melanomas
Unfortunately, it is commonly regarded as an immunotolerant form of cell demise because the phagocytic clearance of apoptotic tumor cells by macrophages can enhance immunosuppression within the TME and prevent stimulation of the host immune system 3
