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Bufalin inhibits the proliferation of lung cancer cells by suppressing hippo-yap pathway
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However, this glycolytic reserve is attenuated in AMs from smokers and in AMs infected with both live attenuated Mtb H37Ra and irradiated Mtb H37Rv strains (30)

While direct evidence supporting P9 targeting oxidative stress regulatory molecules is still lacking, the current findings indicate its potential to indirectly alleviate oxidative stress associated with metabolic disorders via coordinated UCP-1-dependent thermogenic activation and GLP-1-mediated metabolic modulation

Thus iron metabolism plays a central role in regulating mitochondrial metabolism pathways
