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Felger JC, Alagbe O, Hu F, Mook D, Freeman AA, Sanchez MM et al (2007)

Gallbladder issues: Rapid weight loss, regardless of the method, can increase the risk of gallstone formation

There is no evidence that doses above 500mcg produce proportionally better results, and clinical trials using 1mg daily did not dramatically outperform lower doses

In addition, potential confounding factors such as age and sex, lifestyle, substance use, genetic factors and nutritional status need to be considered

Orders may arrive with the previous label during this transition period
