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Description
The treatment of mice with daidzein and genistein (low dose 20 mg/kg or high dose 150200 mg/kg) for two weeks reversed the polyinosinic:polycytidylic acid [poly(I:C)]-induced decrease in locomotor activity and brain/skin gene expression, as well as serum levels of pro-inflammatory mediators relevant to CFS (i.e., TNF-, IL-6, keratinocytes-derived chemokine (IL-8/(CXC motif) ligand (CXC)L8 murine homolog), chemokine (CC motif) ligand-2, -4, -5 (CCL2, CCL4, CCL5) and C-X-C motif chemokine ligand 10 (CXCL10))
Wijffels MC, Kirchhof CJ, Dorland R, Allessie MA
L.SpinazzolaA
They lack 5cap and most were predicted in silico to target multiple mtDNA sites
Psychopharmacology (Berl) 104 : 255259 Papp M, Klimek V, Willner P
