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Injecting GDF-6 into the IVD attenuated inflammatory gene expression and improved disc degeneration in a rabbit puncture model (Miyazaki et al., 2018)

Li YL, Fan J, Cheng XL, Jin HY, Wang Y, Wei F, et al

Risks are generally low but not zero

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Later, in vitro and in vivo studies indicated that an increase in the mRNA expression of peroxisome proliferator-activated receptor (PPAR)- and PPARG in the livers and kidneys of rats with DN was observed when HKC was administered (IG) at doses of 75, 135, and 300 mg/kg for 84 days