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The Journal of clinical endocrinology and metabolism, 91(12), 47924797
Whereas in vitro experiments showed that S375 is phosphorylated by GRK5 upon morphine exposure (Doll et al., 2012) and S375 phosphorylation plays a major role in MOR desensitization (Schulz et al., 2004), S375A knock-in mice still present anti-nociceptive tolerance upon acute and chronic exposure to morphine (Grecksch et al., 2011)
That is often the difference between a formula that looks good on paper and one that gets finished

Types of Reclassification (Switching) The legal status of a medicine is changed when there is growing confidence in the medicines action and safety profile

Junctional adhesion molecule-A deletion increases phagocytosis and improves survival in a murine model of sepsis